The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle

Authors

  • Stephen Cooper Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor Michigan, The Center for Cell Cycle Analysis, Longboat Key, Florida

DOI:

https://doi.org/10.4467/2543702XSHS.17.013.7714

Keywords:

Ludwik Fleck, G0, G1, Restriction Point, Rate-Change Point, Eukaryotic Cell Cycle, Gene Expression in Cell Cycle

Abstract

The concepts of Ludwik Fleck (1896–1961), a microbiologist, historian, and philosopher of medicine, can be used to analyze the conservative nature of scientific ideas. This is discussed and applied to ideas dominant in the understanding of the eukaryotic cell cycle. These are (a) the G1-phase restriction point as a regulatory element of the mammalian cell cycle, (b) the Rate Change Point proposed to exist in fission yeast, and (c) the proposal that a large number of genes are expressed in a cell-cycle-dependent manner.

Fleck proposed that scientific ideas become fixed and difficult to change because criticisms of current and dominant models are either ignored or turned to support of the current model. The idea of a thought-collective leading to the stability of scientific ideas is a central theme of the theory of Ludwik Fleck.

Author Biography

Stephen Cooper, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor Michigan, The Center for Cell Cycle Analysis, Longboat Key, Florida

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18-12-2017

How to Cite

Cooper, S. (2017). The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle. Studia Historiae Scientiarum, 16, 335–364. https://doi.org/10.4467/2543702XSHS.17.013.7714

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SCIENCE BEYOND BORDERS